Rat to Human Extrapolation of HCFC-123 Kinetics Deduced from Halothane Kinetics: A Corollary Approach to Physiologically Based Pharmacokinetic Modeling
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چکیده
منابع مشابه
Rat to human extrapolation of HCFC-123 kinetics deduced from halothane kinetics: a corollary approach to physiologically based pharmacokinetic modeling.
The goal of this study was to develop a human physiologically based pharmacokinetic (PBPK) model for the chemical HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) and its major metabolite, trifluoroacetic acid (TFA). No human kinetic data for HCFC-123 are available, thus a corollary approach was developed. HCFC-123 is a structural analog of the common anesthetic agent halothane (2-bromo-2-chloro-1...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1996
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/30.1.55